Informace o publikaci
OPTIMIZATION OF EXPRESSSION AND PURIFICATION OF FRAGMENT FROM TAU PROTEIN
| Autoři | |
|---|---|
| Rok publikování | 2020 |
| Druh | Konferenční abstrakty |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | Tau protein is abundant in the central nervous system, where it stabilizes microtubules by binding to the interface between tubulin sub-units [1,2]. Hyperphosphorylation of Tau leads to aggregation of protein and disruption of normal function of the neurons. These disorders can cause neurodegenerative diseases such as Alzheimer’s disease or Parkinson’s disease [3,4]. This work is focused on a short fragment from Tau protein, which has a key role in microtubule binding [2]. |
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