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Uveální melanom u 15leté dívky. Kazuistika

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ŽAJDLÍKOVÁ Barbora AUTRATA Rudolf KREJČÍŘOVÁ Inka LAZARČÍKOVÁ Veronika HEISSIGEROVÁ Jarmila DIBLÍK Pavel GLEZGOVÁ Johana VYSLOUŽILOVÁ Daniela JEŽOVÁ Marta ŠACH Jan AUTRATA Daniel

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Česká a slovenská oftalmologie
Citace
Klíčová slova choroidal melanoma, children, enucleation, metastasis
Popis Uveal melanoma is the most common intraocular tumour in adults, it is a form of cancer that affects mostly older adults, as the average age at detection of this tumour is 60 years, but it can occur in any age group with no significant gender difference. However, uveal melanoma is very rare in children compared to the adult population, accounting for 1 % of all cases. In pediatric patients, malignant uveal melanoma is more frequently manifested during puberty, leading to speculation of an association between uveal melanoma and growth hormone levels. Prognostic factors for uveal melanoma include tumour histology, chromosomal abnormalities, tumour size, extrascleral spread and tumour location. Risk factors for uveal melanoma include melanocytosis, neurofibromatosis type 1 and dysplastic naevus syndrome. Some studies point to a significantly lower risk of developing metastases in younger patients, but the prognosis of uveal melanoma in children is not yet fully known. Clinical signs and treatment options for malignant uveal melanoma in children are still under discussion. Differential diagnosis of uveal lesions in children can sometimes be very difficult, as evidenced by following case report in which authors describe a case of choroidal melanoma in a 15-year-old girl.

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