Informace o publikaci

Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017

Autoři	KOHLMAIER B. SCHWEINTZGER N. SAGMEISTER M. SVENDOVA Vendula KOHLFURST D. SONNLEITNER A. LEITNER M. BERGHOLD A. SCHMIEDBERGER E. FAZEKAS F. PICHLER A. REJC-MARKO J. RUZEK Daniel DUFKOVA Lucie CEJKOVA Darina HUSA Petr PÝCHOVÁ Martina KRBKOVÁ Lenka CHMELIK Vaclav STRUNCOVA Vera ZAVADSKA D. KARELIS G. MICKIENE A. ZAJKOWSKA J. BOGOVIC P. STRLE F. ZENZ W.
Rok publikování	2021
Druh	Článek v odborném periodiku
Časopis / Zdroj	Microorganisms
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://www.mdpi.com/2076-2607/9/7/1420
Doi	http://dx.doi.org/10.3390/microorganisms9071420
Klíčová slova	tick-borne encephalitis; vaccine-preventable disease; meningomyelitis; central paresis; peripheral paresis
Popis	Tick-borne encephalitis (TBE) virus is a major cause of central nervous system infections in endemic countries. Here, we present clinical and laboratory characteristics of a large international cohort of patients with confirmed TBE using a uniform clinical protocol. Patients were recruited in eight centers from six European countries between 2010 and 2017. A detailed description of clinical signs and symptoms was recorded. The obtained information enabled a reliable classification in 553 of 555 patients: 207 (37.3%) had meningitis, 273 (49.2%) meningoencephalitis, 15 (2.7%) meningomyelitis, and 58 (10.5%) meningoencephalomyelitis; 41 (7.4%) patients had a peripheral paresis of extremities, 13 (2.3%) a central paresis of extremities, and 25 (4.5%) had single or multiple cranial nerve palsies. Five (0.9%) patients died during acute illness. Outcome at discharge was recorded in 298 patients. Of 176 (59.1%) patients with incomplete recovery, 80 (27%) displayed persisting symptoms or signs without recovery expectation. This study provides further evidence that TBE is a severe disease with a large proportion of patients with incomplete recovery. We suggest monitoring TBE in endemic European countries using a uniform protocol to record the full clinical spectrum of the disease.