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Spray-dried microparticles containing ciprofloxacin for pulmonary delivery

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PEŠTÁLOVÁ Andrea PAVLOKOVÁ Sylvie GAJDZIOK Jan

Rok publikování 2023
Druh Další prezentace na konferencích
Fakulta / Pracoviště MU

Farmaceutická fakulta

Citace
Popis Inhalation therapy of cystic fibrosis using a dry powder inhaler (DPI) is currently being studied in many clinical trials. One possible treatment option is the administration of fluroqinolones in the treatment of P. aeruginosa infections and have been proven to reduce the bacterial load in the lungs and improve patients’ lung function. In order for antibiotic therapy to be effective, the formulation should focus on the parameters particles should have, especially their size and shape, porosity or aerosolisation properties. For the formulation of dry powders, the most common are spray technologies and also the addition of excipients such as porogens or substances from the amino acid group can modify the resulting properties. The aim was to optimize the drying conditions to produce aerodynamically suitable particles. In the next step, particles containing ciprofloxacin were formulated. The resulting particles were evaluated in terms of morphology, flow properties and geometric or aerodynamic diameter respectively.
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