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Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)

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GOVARTS Eva GILLES Liese MARTIN Laura Rodriguez SANTONEN Tiina APEL Petra ALVITO Paula ANASTASI Elena ANDERSEN Helle Raun ANDERSSON Anna-Maria ANDRÝSKOVÁ Lenka ANTIGNACJ Jean-Philippe APPENZELLER Brice BARBONE Fabio BARNETT-ITZHAKI Zohar BAROUKI Robert BERMAN Tamar BIL Wieneke BORGES Teresa BUEKERS Jurgen CANAS-PORTILLA Ana COVACI Adrian CSAKO Zsofia ELLY Den Hond DVORAKOVA Darina FABELOVA Lucia FLETCHERX Tony FREDERIKSEN Hanne GABRIEL Catherine GANZLEBEN Catherine GOEN Thomas HALLDORSSON Thorhallur I. HAUG Line S. HORVAT Milena HUUSKONEN Pasi IMBODEN Medea HUDOBIVNIK Marta Jagodic JANASIK Beata HOLCER Natasa Janev KARAKITSIOS Spyros KATSONOURI Andromachi KLÁNOVÁ Jana KOKARAKI Venetia JENSEN Tina Kold KOPONEN Jani LAEREMANS Michelle LAGUZZI Federica LANGE Rosa LEMKE Nora LIGNELL Sanna LINDROOS Anna Karin VICENTE Joana Lobo LUIJTEN Mirjam MAKRIS Konstantinos C. MAZEJ Darja MELYMUK Lisa Emily MESLIN Matthieu MOLAR Hans MONTAZERI Parisa MURAWSKI Aline NAMORADO Sonia NIEMANN Lars NABLER Stefanie NUNES Baltazar OLAFSDOTTIR Kristin MURINOVA Lubica Palkovicova PAPAIOANNOU Nafsika PEDRAZA-DIAZ Susana PILER Pavel PLICHTA Veronika POTESER Michael PROBST-HENSCH Nicole RAMBAUD Loic RAUSCHER-GABERNIG Elke RAUSOVA Katarina REMY Sylvie RIOU Margaux ROSOLEN Valentina ROUSSELLE Christophe RATHER Maria SARIGIANNIS Denis SILVA Maria J. SLEJKOVEC Zdenka TRATNIK Janja Snoj STAJNKO Anja SZIGETI Tamas JOSE V. Tarazona THOMSEN Cathrine TKALEC Ziga TOLONEN Hanna TRNOVEC Tomas UHL Maria AN Van Nieuwenhuyse VASCO Elsa VERHEYEN Veerle J. VIEGAS Susana VINGGAARD Anne Marie VOGEL Nina VORKAMP Katrin WASOWICZ Wojciech WEBER Till WIMMEROVA Sona WOUTERSEN Marjolijn ZIMMERMANN Philipp ZVONAŘ Martin KOCH Holger KOLOSSA-GEHRING Marike LOPEZ Marta Esteban CASTANO Argelia STEWARTX Lorraine SEPAIX Ovnair SCHOETERS Greet

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj International Journal of Hygiene and Environmental Health
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S143846392300010X?via%3Dihub
Doi http://dx.doi.org/10.1016/j.ijheh.2023.114119
Klíčová slova Human biomonitoring (HBM); Children; Teenagers; Adults; Exposure biomarkers; HBM4EU
Přiložené soubory
Popis As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6-12 years, (ii) 3,117 teenagers aged 12-18 years and (iii) 4,102 young adults aged 20-39 years. The participants were recruited between 2014 and 2021 in 11-12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per-and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzo-phenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from house-holds with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educational attainment. Geographical variations were seen for all exposure biomarkers. For 15 biomarkers, the available health-based HBM guidance values were exceeded with highest exceedance rates for toxicologically relevant arsenic in teenagers (40%), 3-PBA in children (36%), and between 11 and 14% for total DON, Sigma (PFOA + PFNA + PFHxS + PFOS), bisphenol S and cadmium. The infrastructure and harmonized approach succeeded in obtaining comparable European wide internal exposure data for a prioritized set of 11 chemical groups. These data serve as a reference for comparison at the global level, provide a baseline to compare the efficacy of the European Commission's chemical strategy for sustainability and will give leverage to national policy makers for the implementation of targeted measures.
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