Informace o publikaci

Parkinson´s disease cardiovascular symptoms: A new complex functional and structural insight

Autoři

KINCL Vladimír PANOVSKÝ Roman BOČKOVÁ Martina REKTOR Ivan MOJICA-PISCIOTTI Mary Luz MÁCHAL Jan

Rok publikování 2024
Druh Článek v odborném periodiku
Časopis / Zdroj European Journal of Neurology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://onlinelibrary.wiley.com/doi/10.1111/ene.16110
Doi http://dx.doi.org/10.1111/ene.16110
Klíčová slova Parkinson´s disease; cardiovascular symptoms
Popis Background The known impairments of the cardiovascular system in Parkinson´s disease (PD) are caused by autonomic dysfunction and manifested mainly in postural hypotension, chronotropic insufficiency, and reduced heart rate variability. Other dysfunctions, mainly stress response, arrhythmia occurrence, and heart morphology changes, are still the subject of research. Objectives To assess the heart rate and blood pressure reaction during exercise, advanced measurements of heart volumes and mass using cardiac magnetic resonance (CMR), and occurrence of arrhythmias in PD patients. Methods Thirty PD patients (19 men, mean age 57.5?years) without known cardiac comorbidities underwent bicycle ergometry, electrocardiogram Holter monitoring and CMR. Exercise and CMR parameters were compared with controls (24 subjects for ergometry, 20 for CMR). Results PD patients had lower baseline systolic blood pressure (SBP) (117.8 vs. 128.3?mmHg, p?<?0.01), peak SBP (155.8 vs. 170.8?mmHg, p?<?0.05), and lower heart rate increase (49.7 vs. 64.3 beats per minute, p?<?0.01). PD patients had higher indexed left and right ventricular end-diastolic volumes (68.5 vs. 57.3, p?=?0.003 and 73.5 vs. 61.0?mL/m2, respectively) and also indexed left and right ventricular end-systolic volumes (44.1 vs. 39.0, p?=?0.013 and 29.0 vs. 22.0?mL/m2, p?=?0.013, respectively). A high prevalence of atrial fibrillation (8 subjects, 26.7%) was found. Conclusions This novel study combining functional and structural approaches showed that PD is linked with weaker blood pressure and heart rate reaction during exercise, increased myocardial mass and heart volumes compared to controls, and a high prevalence of atrial fibrillation.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info