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A critical review to identify data gaps and improve risk assessment of bisphenol A alternatives for human health

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MHAOUTY-KODJA Sakina ZALKO Daniel TAIT Sabrina TESTAI Emanuela VIGUIE Catherine CORSINI Emanuela GROVA Nathalie BURATTI Franca Maria CABATON Nicolas J. COPPOLA Lucia ANTONIO de la Vieja DUSINSKA Maria NAOUALE El Yamani GALBIATI Valentina IGLESIAS-HERNANDEZ Patricia KOHL Yvonne MADDALON Ambra MARCON Francesca NAULE Lydie RUNDEN-PRAN Elise SALANI Francesca SANTORI Nicoletta TORRES-RUIZ Monica TURNER Jonathan D. ADAMOVSKÝ Ondřej AIELLO-HOLDEN Kiara DIRVEN Hubert LOURO Henriqueta SILVA Maria Joao

Rok publikování 2024
Druh Článek v odborném periodiku
Časopis / Zdroj CRITICAL REVIEWS IN TOXICOLOGY
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://www.tandfonline.com/doi/full/10.1080/10408444.2024.2388712
Doi http://dx.doi.org/10.1080/10408444.2024.2388712
Klíčová slova Bisphenol A alternatives; endocrine disruption; metabolism; toxicokinetic; immunotoxicity; developmental neurotoxicity; genotoxicity; carcinogenesis; human health
Přiložené soubory
Popis Bisphenol A (BPA), a synthetic chemical widely used in the production of polycarbonate plastic and epoxy resins, has been associated with a variety of adverse effects in humans including metabolic, immunological, reproductive, and neurodevelopmental effects, raising concern about its health impact. In the EU, it has been classified as toxic to reproduction and as an endocrine disruptor and was thus included in the candidate list of substances of very high concern (SVHC). On this basis, its use has been banned or restricted in some products. As a consequence, industries turned to bisphenol alternatives, such as bisphenol S (BPS) and bisphenol F (BPF), which are now found in various consumer products, as well as in human matrices at a global scale. However, due to their toxicity, these two bisphenols are in the process of being regulated. Other BPA alternatives, whose potential toxicity remains largely unknown due to a knowledge gap, have also started to be used in manufacturing processes. The gradual restriction of the use of BPA underscores the importance of understanding the potential risks associated with its alternatives to avoid regrettable substitutions. This review aims to summarize the current knowledge on the potential hazards related to BPA alternatives prioritized by European Regulatory Agencies based on their regulatory relevance and selected to be studied under the European Partnership for the Assessment of Risks from Chemicals (PARC): BPE, BPAP, BPP, BPZ, BPS-MAE, and TCBPA. The focus is on data related to toxicokinetic, endocrine disruption, immunotoxicity, developmental neurotoxicity, and genotoxicity/carcinogenicity, which were considered the most relevant endpoints to assess the hazard related to those substances. The goal here is to identify the data gaps in BPA alternatives toxicology and hence formulate the future directions that will be taken in the frame of the PARC project, which seeks also to enhance chemical risk assessment methodologies using new approach methodologies (NAMs).
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