Informace o publikaci
Geranylated Flavonoids from Paulownia tomentosa Suppress Cancer Cell Proliferation and Trigger Apoptosis
| Autoři | |
|---|---|
| Rok publikování | 2025 |
| Druh | Další prezentace na konferencích |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | The presence of secondary metabolites in Paulownia tomentosa (Thunb.) Steud. (Paulowniaceae), particularly geranylated flavonoids, has recently garnered significant attention in the search for new biologically active compounds. Although these naturally occurring substances are found in a limited number of plant families, they are noteworthy for their potential pharmacological properties. Recently, geranylated flavonoids have been extensively studied for their various biological activities, which include anti-inflammatory, antibacterial, antioxidant, and cytotoxic effects. In this study, we showed that geranylated flavonoids from Paulownia tomentosa can effectively inhibit the growth of cancer cells, particularly the DU-145 prostate cancer cell line. The tested substances further induce apoptosis and changes in the mitochondrial activity of cancer cells. |
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