Informace o publikaci

Development and validation of the SDLD score: a simplified tool to predict successful endoscopic papillectomy in ampullary lesions

Autoři	TRUNG Kien Vu ABOU-ALI Einas GULLA Aiste SOARES Kevin CAILLOL Fabrice PAIK Woo H NAPOLEON Bertrand HALIMI Asif MASARYK Viliam BRUNO Marco J PÉREZ-CUADRADO-ROBLES Enrique BOLM Louisa SEYFRIED Steffen PETRONE Maria C YILMAZ Bengisu VOLLMER Charles BERGER Arthur MAGGINO Laura SCHEMMER Peter WICHMANN Dörte KARAM Elias DUGIC Ana KUNOVSKÝ Lumír REGNER Sara GAUJOUX Sebastien HOLLENBACH Marcus
Rok publikování	2025
Druh	Článek v odborném periodiku
Časopis / Zdroj	Gastrointestinal Endoscopy
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://www.sciencedirect.com/science/article/pii/S0016510725015111
Doi	https://doi.org/10.1016/j.gie.2025.03.1333
Klíčová slova	ETS1; DNA-PKcs; chemoresistance; triple-negative breast cancer; transcriptional regulation
Popis	Background and Aims Endoscopic papillectomy (EP) is the standard treatment for noninvasive ampullary lesions (ALs), whereas advanced cases require surgery. Managing ALs is challenging and may lead to over- or undertreatment. We developed a score to identify the best candidates for endoscopic or surgical treatment. Methods We analyzed 447 patients who underwent EP. The cohort was randomly split into a training set (n = 325) and validation set (n = 122). Logistic regression identified predictors for incomplete resection (R1), which were incorporated into a 4-item score. Performance was assessed using the area under the receiver-operating characteristic curve (AUROC). Results Independent predictors for R1 included size ?30 mm (S), high-grade dysplasia and/or invasive cancer (D), laterally spreading-lesion (L), and bile or pancreatic duct dilation (D), which we named the SDLD score. ALs with 0 to 1 points had the highest complete resection rates (training, 86.0%; validation, 88.5%), whereas ?2 points significantly increased R1 rates (training, 52.0%; validation, 57.7%; P < .001). The AUROC was 0.792 (training) and 0.708 (validation). Conclusions The SDLD score predicts R1 in EP and aids in treatment decisions.