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Telomerase activity and expression in the course of treatment of acute childhood leukemias

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MALÁSKA Jan FAJKUS Jiří BAJER Milan HRSTKOVÁ Hana BAJEROVÁ Kateřina MICHÁLEK Jaroslav FAJKUSOVÁ Lenka VYZULA Rostislav KREJČÍ Kateřina SKLENIČKOVÁ Marie

Rok publikování 2000
Druh Článek ve sborníku
Konference Miami Nature Biotechnology Short Reporřts, Volume 11m, Advances in Gene Technology: DNA, RNA and CANCER
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
Obor Genetika a molekulární biologie
Klíčová slova Telomerase activity
Popis Samples of blood and marrow from children with leukemia were assayed for telomerase activity and expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis; it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, suggesting involvement of a telomerase-independent mechanism of telomere elongation.
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