Informace o publikaci

Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients

Název česky vyšetření prealbuminu a stopových prvků v séru u pacientů s PKU a HPA ke sledování jejich nutričního stavu
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PROCHÁZKOVÁ Dagmar KOLBOVÁ Lucie JARKOVSKÝ Jiří VINOHRADSKÁ Hana KONEČNÁ Petra DOLEŽEL Zdeněk

Rok publikování 2012
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Popis Aim: Phenylketonuria is an inherited disorder of metabolism of the amino acid phenylalanine caused by a deficit of the enzyme phenylalaninhydroxylase. It is treated with a low-protein diet containing a low content of phenylalanine to prevent mental affection of the patient. The objective of the present study was to assess the compliance of our phenylketonuric (PKU) and hyperphenylalaninemic (HPA) patients; to determine the concentration of serum pre-albumin, selenium, zinc and iron to discover the potential correlation between the amount of proteins in food and their metabolic control. Methods: We studied 174 patients of which 113 were children (age 1-18), 60 with PKU and 53 with HPA and 61 were adults (age 18-42), 51 with PKU and 10 with HPA. Results: We did not prove a statistically significant difference in the concentration of serum pre-albumin, zinc and iron among the respective groups. We approved statistically significant difference in serum selenium concentrations of adult PKU and HPA patients (p=0.006; Mann-Whitney U test). Conclusions: The concentration of serum selenium could be used as indirect marker in evaluation of the risk of late complications of dietary therapy.

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