Informace o publikaci

Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

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KOVÁŘ David MALÁ Aneta VAŇÁČKOVÁ Jitka KALINA Michal FOHLEROVÁ Zdenka HLAVÁČEK Antonín FARKA Zdeněk SKLÁDAL Petr STARČUK Zenon JIŘÍK Radovan SLABÝ Ondřej HUBÁLEK Jaromír

Rok publikování 2017
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Nanomaterials
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://www.hindawi.com/journals/jnm/2017/7859289/
Doi http://dx.doi.org/10.1155/2017/7859289
Obor Biochemie
Klíčová slova ATOMIC-FORCE MICROSCOPY; CONTRAST AGENTS; ONE-STEP; MEDIA; MRI; SEPARATION; PARTICLES; SILICA; PROBES; CHARGE
Popis Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. Thecitrate-stabilised particles were produced with a narrow average size range below 2nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI)was then evaluated. The relaxivities (r(1),r(2)) and r(2)/r(1) ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T-2-contrast probe.
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