Informace o publikaci

HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment

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JOHARD H. OMELYANENKO A. FEI G. ZILBERTER M. DAVE Z. ABU-YOUSSEF R. SCHMIDT L. HARISANKAR A. VINCENT C.T. WALFRIDSSON J. NELANDER S. HARKANY T. BLOMGREN K. ANDÄNG Michael

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj MOLECULAR CANCER RESEARCH
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://mcr.aacrjournals.org/content/18/10/1522
Doi http://dx.doi.org/10.1158/1541-7786.MCR-20-0292
Klíčová slova LONG-TERM; ADULT; NEUROGENESIS; CYCLE; IRRADIATION; RECEPTOR; PURIFICATION; HIPPOCAMPUS; DYNAMICS; CULTURE
Popis Children suffering from neurologic cancers undergoing chemotherapy and radiotherapy are at high risk of reduced neurocognitive abilities likely via damage to proliferating neural stem cells (NSC). Therefore, strategies to protect NSCs are needed. We argue that induced cell-cycle arrest/quiescence in NSCs during cancer treatment can represent such a strategy. Here, we show that hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels are dynamically expressed over the cell cycle in NSCs, depolarize the membrane potential, underlie spontaneous calcium oscillations and are required to maintain NSCs in the actively proliferating pool. Hyperpolarizing pharmacologic inhibition of HCN channels during exposure to ionizing radiation protects NSCs cells in neurogenic brain regions of young mice. In contrast, brain tumor-initiating cells, which also express HCN channels, remain proliferative during HCN inhibition.
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