Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension.
|Druh||Článek v odborném periodiku|
|Časopis / Zdroj||Gynecologic and Obstetric Investigation|
|Fakulta / Pracoviště MU|
|Obor||Genetika a molekulární biologie|
|Klíčová slova||pregnancy-induced hypertension; preeclampsia; genetic polymorphism; matrix metalloproteinase 1|
|Popis||In preeclampsia the cytotrophoblast invasion of the decidual vessels is reduced. The endothelia in the decidual vessels may influence the cytotrophoblast invasion and remodeling of decidual spiral arteries. The decidual endothelial cells from preeclamptic placentas produce less MMP1 than those from normal placentas. MMPs form group of enzymes that is capable of degrading components of extracellular matrix components. The present study investigated the prevalence and possible association of an insertion of guanine in the promoter of the MMP1 gene with pregnancy-induced hypertension, preeclampsia and eclampsia in the Czech population. This was a case control study. No differences were observed in genotype frequencies between cases and controls. The insertion of the guanine in the promoter of the MMP1 gene does not appear to increase the risk of development of pregnancy-induced hypertension, preeclampsia and eclampsia.|